Find work
that fits
your next move.

Job OBJECTIVES/PURPOSE Leads the global Oral Drug Product organization and delivery of oral drug product development from early phase through commercialization and lifecycle management.

Risk Management • Provide direction on claims management strategy Evaluation of small to large exposure claims with TPA’s and claims handlers Liaison with Takeda Legal Counsel on claims management procedure and litigated claim strategy Communication with site stakeholders and carrier claims teams Invoice and settlement payment reconciliation Preparation of open claims reports across multiple lines of business Claims audit and review activities • Support Risk Engineering Program - actively working with GIRM team and GMS Engineering • Lead to support the business with fire risk engineering • Support CAPEX Insurance Process and Engineering Plan Reviews • Support GIRM risk projects from time to time • Support the business on critical global contractual risk reviews and determine appropriate types and level of insurance Additional Responsibilities Responsibility for/ Oversee (with support from GIRM team) the development and implementation of any insurance Management Information systems using them to streamline insurance administration, driving out time and cost • Deliver Global Insurance awareness training to key internal stakeholder groups Participate in and lead ad hoc risk management and other business projects as required Onboarding and training of GIRM team (new members or when new initiatives/ processes are implemented) EDUCATION, BEHAVIOURAL COMPETENCIES AND SKILLS • Bachelor's degree required, preferably with a concentration in Economics, Finance, Business, Law. • Strong experience in insurance risk management role in insurance/ risk industry (client facing or as a buyer) • Strong understanding of global insurance programs and client servicing • Knowledge and expertise of the global insurance markets • Knowledge of global insurance legislation, regulations and local market practice • Strong US network within the broking and insurer communities Association of Chartered Insurance Institute qualified or part qualified or Degree/ Alternative strong and relevant academic achievements.

Job Director, Computational & AI Biologics Design Lead Takeda Research is constructing a Lab of Tomorrow built on AI, automation, new ways of working, and talent with the singular vision of delivering differentiated medicines to the clinic at speed and cost.

What’s Different About This Role Biotech-like autonomy with big pharma scale AI-native biologics discovery environment Streamlined governance with rapid decision-making Direct impact on future operating models in R&D Takeda Compensation and Benefits Summary We understand compensation is an important factor as you consider the next step in your career.

656.10, you are hereby notified that an application for Alien Employment Certification will be filed by Takeda Pharmaceuticals USA, Inc. for the following job opportunity: JOB LOCATION Cambridge, MA POSITION Network Platform • Architect POSITION Takeda Pharmaceuticals USA, Inc. is seeking a Network Platform • Architect with the following duties • Lead the formulation of PEP related IT Strategy, with a strong focus on Takeda strategic digital innovation goals by maturing Takeda patient engagement capabilities. • Drive PEP adoption, while maintaining design authority to align use cases and regional concerns to an optimized, reusable platform. • Lead and influence the development and maintenance of reference architecture, design, engineering, blueprints, standards, and product management.

The Senior EHS Specialist II serves as a strategic EHS leader and technical expert partnering closely with manufacturing, laboratory, warehouse, and engineering teams to drive a proactive safety culture and ensure compliance excellence.

Accountabilities • Lead and manage multiple biologic drug discovery projects in an AI-forward manner with urgency; oversee the entire discovery process from modality selection through preclinical development and IND filing • Define, articulate, and evolve the program strategy for antibody, bispecific, fusion protein, or other large molecule modalities; build the medicine vision and early asset strategy including developability and manufacturability considerations • Evaluate and prioritize biologic candidates based on scientific, clinical, CMC, and commercial considerations; balance potency, selectivity, half-life, immunogenicity risk, protein stability and expression yield in go/no-go decisions • Lead and enable rapid, AI-enabled • Design and Test cycles for protein engineering; ensure generative protein design and structure-prediction outputs are translated into clear experimental recommendations and fast, decisive go/no-go outcomes • Drive sequence optimization, affinity maturation, Fc engineering, and formulation-ready candidate selection using integrated computational and experimental platforms • Partner with Clinical and Translational teams to refine asset strategy; ensure clinical line of sight from early discovery including patient selection, biomarker strategy, and dose projection from PK/PD modeling • Manage external CROs and CDMOs providing protein expression, purification, in vitro pharmacology, and GLP toxicology services; ensure timelines are met and data is decision-ready Represent Takeda externally for AIRx Biologics; evaluate external opportunities including platform technologies, novel modalities, and in-licensing candidates; serve as BD ambassador • Ensure programs are delivered at pace with disciplined cost stewardship, contributing to a sustainable, high-quality pipeline of biologic INDs and informing broader portfolio strategy Qualifications & Competencies Advanced degree in protein biochemistry, structural biology, molecular biology, immunology, or related life sciences (PhD, MD, or DVM); PhD strongly preferred 15+ years of industry experience with deep subject matter expertise in biologic drug discovery; at least 10 years in scientific leadership roles within large molecule programs • Proven track record leading 5+ biologic programs across discovery from target inception to Candidate Nomination or beyond; minimum 3 biologic INDs required (antibody, bispecific, or fusion protein programs preferred) Deep knowledge of the biologic drug discovery and development process target identification, hit generation (phage/yeast display, hybridoma, single B cell), lead optimization, developability assessment, and IND-enabling CMC and toxicology activities Expertise in protein engineering principles affinity maturation, CDR optimization, Fc engineering, bispecific/multispecific antibody formats, linker design, and fusion protein architecture • Strong AI/ML exposure and digital-forward scientific mindset; experience leveraging AI in protein design Solid understanding of large molecule DMPK FcRn-mediated recycling, half-life extension strategies, subcutaneous absorption, immunogenicity risk assessment, and PK/PD modeling for dose projection • Familiarity with biologic CMC considerations expression systems (different hosts and stable cell line generation), purification, analytical characterization, and early formulation development as inputs to candidate selection Excellent and inclusive leadership; able to inspire and motivate cross-functional protein engineering, biology, and translational teams towards ambitious goals Exceptional communication skills; able to convey complex large molecule science to senior governance audiences and distill developability trade-offs into clear strategic recommendations Demonstrated success building strategic CRO and CDMO partnerships for biologics; strong business acumen including regulatory (BLA/MAA pathway) and commercial awareness Additional Information The position will be based in Cambridge, MA.

Excellent communication skill set is a must. ​ What you bring to Takeda Bachelor’s degree in Engineering required, preferably in Chemical, Electrical, Mechanical, Controls, or related engineering discipline. • Minimum 2+ years of experience supporting manufacturing automation, controls systems, or engineering operations within a production environment. • Hands-on experience or strong familiarity with automation platforms such as DeltaV, PLC systems (Siemens/Rockwell), MES/EBM systems, or Building Automation Systems (BAS) preferred.

How You Will Contribute • Serve as the primary subject matter expert for control systems (PLC, DCS, MES, and ancillary data systems) • Support manufacturing operations by troubleshooting issues and ensuring system reliability and compliance • Lead the full project lifecycle from design through implementation for small to large-scale automation initiatives • Define project scope, strategy, and requirements while ensuring high-quality, timely delivery of solutions Oversee and review technical outputs of automation engineering work • Drive continuous improvement, system performance optimization, and innovation initiatives • Collaborate cross-functionally through daily operational and project meetings • Support audits, inspections, and compliance activities by preparing and presenting required data • Develop and maintain SOPs, work instructions, and engineering standards for automation programs • Ensure accurate documentation and lifecycle management of system specifications, drawings, and data Skills and Qualifications • Bachelor’s or Master’s degree in Chemical Engineering, Electrical Engineering, Computer Science, or a related field 8+ years of experience in industrial automation or control systems engineering • Strong expertise with DeltaV or similar DCS platforms and PLC programming • Experience in cGMP, pharmaceutical, biotechnology, or other regulated environments • Knowledge of ISA-S88/ISA-S95 standards and batch or continuous manufacturing processes Solid understanding of industrial control systems, instrumentation, and networking (e.g., Ethernet/IP, Profibus) • Experience with data historians, reporting systems, and integration tools (e.g., OPC, SCADA platforms) Demonstrated ability to lead complex projects and deliver solutions aligned with business goals • Familiarity with system validation, commissioning, and qualification processes • Strong problem-solving, communication, and cross-functional collaboration skills Takeda Compensation and Benefits Summary We understand compensation is an important factor as you consider the next step in your career.

Serve as the lead coordinator for annual facility shutdowns, including planning, scheduling, resource coordination, issue escalation, and execution oversight. • Manage and support critical utility systems including HVAC, clean steam, WFI, RO water, compressed air, and related facility infrastructure. • Develop and implement KPIs to monitor utility system performance, landlord-managed services, and facility reliability metrics. • Lead facility-related change controls, risk assessments, deviations, investigations, and CAPA activities while ensuring compliance with GMP requirements. • Manage external vendors, contractors, and service providers to ensure adherence to Takeda's safety, quality, and technical standards. • Partner with Validation, Quality, Manufacturing, Maintenance, and Engineering teams to deliver compliant and sustainable engineering solutions. • Support deployment and continuous improvement of engineering standards, procedures, documentation, and best practices. • Provide technical expertise during regulatory inspections, internal audits, and quality assessments related to facility systems and infrastructure. • Lead sustainability and energy reduction projects that support site performance goals and Takeda's environmental commitments. • Develop project schedules, cost estimates, budgets, and implementation plans while ensuring projects are delivered safely, on time, and within budget. • Support facility security and infrastructure improvement projects, including access control and facility monitoring systems as needed. • Mentor junior engineers and serve as a technical resource for cross-functional teams. • Identify risks proactively and implement mitigation strategies to support business continuity and operational excellence.

Job • The Head of Corporate Strategy is responsible for shaping and driving the long-term strategic direction of Takeda, ensuring that scientific innovation, commercial excellence, and disciplined investment decisions translate into meaningful patient impact.

As part of DQS, the Quantitative Clinical Pharmacology (QCP) Team at Takeda consists of therapeutically aligned teams who drive the clinical pharmacology strategy from pre-FIH through life-cycle management within the global project team.

Job • We are seeking a hands-on innovative seasoned Data Science professional for the Associate Director, Predictive Analytics position out of our Cambridge, Ma office to lead advanced analytics for Takeda’s US GI Franchise.

Job • Responsible for identification of learning needs, development and execution of strategic, tailored training plans and packages, and measurement of training success for Medical Affairs Scientific Training plans within GMAO, which includes ongoing needs assessments, developing and updating training programs, and establishing reinforcement training, including booster and focal training, to drive continual enhancement of GMAO scientific knowledge of Takeda Oncology marketed and pipeline products, relevant disease states, and competitor data • Ensure strategic collaboration with regions and countries to better understand training needs and deliver programs that meet these needs • Work with and oversee vendors to help support training initiatives.

Job About the role • Join our team as an Associate Director, Medical Content and be a strategic partner within the US Medical Content Hub, responsible for the development and execution of the medical content strategy across the dermatology and rheumatology therapeutic area.

POSITION OBJECTIVES • The Senior Director, Head of Medical Review Supports Global PSPV with an emphasis on overseeing medical assessment of individual case safety reports from investigational and marketed products across all therapeutic areas. • Responsible for overseeing high quality medical assessment of individual case safety reports in the Global Safety Database to ensure compliance with domestic and international regulations. • Leads and manages global medical review and provide medical oversight for outsourced medical review activities.

The Director Global Regulatory Affairs, Neuroscience is responsible for developing innovative global regulatory strategies and providing strategic regulatory guidance for the global development of various products within the Neuroscience Therapeutic Area Unit (TAU) portfolio .

Job About the role • In conjunction with Senior Director, Brand Strategy and Operations, develop patient assistance strategies and tactics aligned to support overall Takeda and Patient Access priorities This role will be highly collaborative across multiple stakeholders within Patient Access and across the USBU Managing PAP partners in support of Takeda programs including contract negotiation, performance management, training, adhering to business rules and SOPs How you will contribute Developing and implementing appropriate Takeda procedures and business rules.

As Senior Director and Regulatory Platform Lead GRA CMC, Device and Drug-Device Combinations Human Factors, you will provide leadership for the development and implementation of innovative pure device and combination product regulatory strategies particularly pertaining to the development, registration, commercialization and life cycle management with a focus on Human Factors, ensuring that regulatory filings are of high quality and right first time How you will contribute • Maintain up-to-date knowledge and expertise of relevant CMC and quality guidelines and regulations, with emphasis on Human Factors, and establishes mechanisms to communicate them to relevant stakeholders, thereby driving prospective and proactive implementation.

Job • Join Takeda as an Associate Director, Market Access and Channel Strategy within U.S. Patient and Market Access (PAMA) out of our Cambridge or Lexington, MA office.